Dysregulated proinflammatory and fibrogenic phenotype of fibroblasts in cystic fibrosis.
Morbi-mortality in cystic fibrosis (CF) is mainly related to chronic lung socksmith santa cruz infection and inflammation, uncontrolled tissue rearrangements and fibrosis, and yet the underlying mechanisms remain largely unknown.We evaluated inflammatory and fibrosis responses to bleomycin in F508del homozygous and wild-type mice, and phenotype of